Zinc Status and Risk of Cardiovascular Diseases and Type 2 Diabetes Mellitus—A Systematic Review of Prospective Cohort Studies
نویسندگان
چکیده
Zinc is an essential trace element with proposed therapeutic effects in Type 2 diabetes mellitus (DM), however, the associations between zinc status and the prospective risks of cardiovascular diseases (CVD) and Type 2 DM have not been evaluated. The current systematic review aims to determine the relationships between zinc intake or plasma/serum zinc levels and prospective incidence of CVD and Type 2 DM. Fourteen papers describing prospective cohort studies were included, reporting either CVD (n = 91,708) and/or Type 2 DM (n = 334,387) outcomes. Primary analyses from four out of five studies reported no association between zinc intake and CVD events, when adjusted for multiple variables. Higher serum zinc level was associated with lower risk of CVD in three out of five studies; pronounced effects were observed in vulnerable populations, specifically those with Type 2 DM and patients referred to coronary angiography. The limited evidence available suggests no association between zinc status and Type 2 DM risk. Further investigations into the mechanisms of zinc's action on the pathogenesis of chronic diseases and additional evidence from observational studies are required to establish a recommendation for dietary zinc in relation to the prevention of CVD and Type 2 DM.
منابع مشابه
Association between Adiponectin Concentrations and Cardiovascular Disease in Diabetic Patients: A Systematic Review and Meta-Analysis
BACKGROUND This systematic review and meta-analysis of prospective studies evaluates the association between adiponectin concentrations and risk of cardiovascular disease (CVD) in individuals with diabetes mellitus (DM). METHODS PubMed and Embase were searched for prospective studies on the association of adiponectin concentrations and risk of CVD up to June 2013. Random-effect model was sele...
متن کاملThe Beneficial Effects of Fiber on Major Chronic Diseases: A Review of Evidence
Background: Fiber is a carbohydrate, which is neither completely digested nor absorbed in the small intestine, but may be fermented and plays a key role in the human health. We investigated the beneficial effects of fiber on major chronic diseases. Methods: It was extracted the relevant articles by searching the PubMed, ScienceDirect, and Scopus databases using the following keywords: dietary f...
متن کاملDoes high sugar consumption exacerbate cardiometabolic risk factors and increase the risk of type 2 diabetes and cardiovascular disease?
Consumption of sugar has been relatively high in the Nordic countries; the impact of sugar intake on metabolic risk factors and related diseases has been debated. The objectives were to assess the effect of sugar intake (sugar-sweetened beverages, sucrose and fructose) on association with type 2 diabetes, cardiovascular disease and related metabolic risk factors (impaired glucose tolerance, ins...
متن کاملRelationship between Spexin Neuropeptide and Cardiovascular Risk Factors in Children and Adolescents: A Systematic Review
Introduction: Spexin, a novel neuropeptide with diverse physiological functions, can be a cardiovascular disease risk assessment biomarker. This study investigated the association between serum spexin concentration and cardiovascular risk factors in children and adolescents. Materials and Methods: A search was conducted to collect studies between January 2007 and March 2021 in the PubMed, Embas...
متن کاملPrevalence of Comorbidities in COVID-19 Patients: A Systematic Review and Meta-Analysis
Background: In this study, we aimed to assess the prevalence of comorbidities in the confirmed COVID-19 patients. Thismight help showing which comorbidity might pose the patients at risk of more severe symptoms.Methods: We searched all relevant databases on April 7th, 2020 using the keywords (“novel coronavirus” OR COVID-19OR SARS-CoV-2 OR Coronavirus) AND (comorbidities OR cl...
متن کامل